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PubChem AID 602151

Compile data set for download or QSAR
Found 147 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258084
PNG
((1R,2R)-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-ben...)
Show SMILES Clc1ccc2n(C3CCN(CCNC(=O)C4C[C@H]4c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C24H27ClN4O2/c25-17-6-7-22-21(14-17)27-24(31)29(22)18-8-11-28(12-9-18)13-10-26-23(30)20-15-19(20)16-4-2-1-3-5-16/h1-7,14,18-20H,8-13,15H2,(H,26,30)(H,27,31)/t19-,20?/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87193
PNG
(5-fluoranyl-N-[(2S)-1-[4-(2-oxidanylidene-3H-benzi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C24H26FN5O2/c1-15(26-23(31)21-13-16-12-17(25)6-7-19(16)27-21)14-29-10-8-18(9-11-29)30-22-5-3-2-4-20(22)28-24(30)32/h2-7,12-13,15,18,27H,8-11,14H2,1H3,(H,26,31)(H,28,32)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87192
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H27N5O2/c1-16(25-23(30)21-14-17-6-2-3-7-19(17)26-21)15-28-12-10-18(11-13-28)29-22-9-5-4-8-20(22)27-24(29)31/h2-9,14,16,18,26H,10-13,15H2,1H3,(H,25,30)(H,27,31)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87183
PNG
(N-[(1R)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H26ClN5O2/c1-15(26-23(31)21-12-16-4-2-3-5-19(16)27-21)14-29-10-8-18(9-11-29)30-22-7-6-17(25)13-20(22)28-24(30)32/h2-7,12-13,15,18,27H,8-11,14H2,1H3,(H,26,31)(H,28,32)/t15-/m1/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87179
PNG
(5-fluoranyl-N-[(2R)-1-(4-oxidanylidene-1-phenyl-1,...)
Show SMILES C[C@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C25H28FN5O2/c1-17(28-23(32)22-14-18-13-19(26)7-8-21(18)29-22)15-30-11-9-25(10-12-30)24(33)27-16-31(25)20-5-3-2-4-6-20/h2-8,13-14,17,29H,9-12,15-16H2,1H3,(H,27,33)(H,28,32)/t17-/m1/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87201
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)COc1ccccc1
Show InChI InChI=1S/C23H28N4O3/c1-17(24-22(28)16-30-19-7-3-2-4-8-19)15-26-13-11-18(12-14-26)27-21-10-6-5-9-20(21)25-23(27)29/h2-10,17-18H,11-16H2,1H3,(H,24,28)(H,25,29)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87226
PNG
(4-fluoranyl-N-[(2S)-1-[4-(6-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-12-17(24)6-7-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87190
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C24H26N4O2S/c1-16(25-23(29)22-14-17-6-2-5-9-21(17)31-22)15-27-12-10-18(11-13-27)28-20-8-4-3-7-19(20)26-24(28)30/h2-9,14,16,18H,10-13,15H2,1H3,(H,25,29)(H,26,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258131
PNG
(CHEMBL492561 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrClN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87228
PNG
(N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27FN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-15-21(27)8-9-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87159
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H27F2N5O2/c1-16(29-23(33)22-12-17-4-2-3-5-21(17)30-22)14-31-10-8-25(9-11-31)24(34)28-15-32(25)18-6-7-19(26)20(27)13-18/h2-7,12-13,16,30H,8-11,14-15H2,1H3,(H,28,34)(H,29,33)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87219
PNG
(N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23ClF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87119
PNG
((1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidaz...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87213
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24BrFN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87214
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87211
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258128
PNG
(CHEMBL493010 | N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc5ccccc5c4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C25H25FN4O2/c26-20-7-8-23-22(16-20)28-25(32)30(23)21-9-12-29(13-10-21)14-11-27-24(31)19-6-5-17-3-1-2-4-18(17)15-19/h1-8,15-16,21H,9-14H2,(H,27,31)(H,28,32)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258181
PNG
(3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(F)c(F)c4)CC3)c2c1
Show InChI InChI=1S/C21H21F3N4O2/c22-14-2-4-18-19(12-14)28(21(30)26-18)15-5-8-27(9-6-15)10-7-25-20(29)13-1-3-16(23)17(24)11-13/h1-4,11-12,15H,5-10H2,(H,25,29)(H,26,30)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87225
PNG
(4-chloranyl-N-[(2S)-1-[4-(6-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-12-17(24)6-7-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258179
PNG
(CHEMBL521990 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87158
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C25H26F3N5O2/c1-15(30-23(34)22-11-16-10-17(26)2-5-21(16)31-22)13-32-8-6-25(7-9-32)24(35)29-14-33(25)18-3-4-19(27)20(28)12-18/h2-5,10-12,15,31H,6-9,13-14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87127
PNG
(4-chloranyl-N-[2-[4-(5-iodanyl-2-oxidanylidene-3H-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(I)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClIN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87211
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87227
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-[4-(6-fluoranyl-2-oxi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F3N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-11-15(23)3-5-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87215
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27BrN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87217
PNG
(4-chloranyl-N-[(2S)-1-[4-(5-chloranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87216
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27BrN4O2/c1-15-3-5-17(6-4-15)22(29)25-16(2)14-27-11-9-19(10-12-27)28-21-8-7-18(24)13-20(21)26-23(28)30/h3-8,13,16,19H,9-12,14H2,1-2H3,(H,25,29)(H,26,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87151
PNG
(N-[(1S)-1-[(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES CC(C)[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C27H33N5O2/c1-19(2)24(30-25(33)23-16-20-8-6-7-11-22(20)29-23)17-31-14-12-27(13-15-31)26(34)28-18-32(27)21-9-4-3-5-10-21/h3-11,16,19,24,29H,12-15,17-18H2,1-2H3,(H,28,34)(H,30,33)/t24-/m1/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258180
PNG
(4-chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-13-16(23)5-6-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87222
PNG
(4-chloranyl-N-[(2S)-1-[4-(5-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87236
PNG
(N-[2-[4-(6-fluoranyl-2-oxidanylidene-3H-benzimidaz...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4cccc5-c6ccccc6C(=O)c45)CC3)c2c1
Show InChI InChI=1S/C28H25FN4O3/c29-17-8-9-23-24(16-17)33(28(36)31-23)18-10-13-32(14-11-18)15-12-30-27(35)22-7-3-6-20-19-4-1-2-5-21(19)26(34)25(20)22/h1-9,16,18H,10-15H2,(H,30,35)(H,31,36)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87230
PNG
(N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27FN4O2/c1-15-3-5-17(6-4-15)22(29)25-16(2)14-27-11-9-19(10-12-27)28-21-13-18(24)7-8-20(21)26-23(28)30/h3-8,13,16,19H,9-12,14H2,1-2H3,(H,25,29)(H,26,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50206160
PNG
(CHEMBL245621 | Halopemide | Halopemide, 8 | N-(2-(...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50206153
PNG
(CHEMBL246032 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C24H25N5O2/c30-23(18-15-17-5-1-2-6-20(17)26-16-18)25-11-14-28-12-9-19(10-13-28)29-22-8-4-3-7-21(22)27-24(29)31/h1-8,15-16,19H,9-14H2,(H,25,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87182
PNG
((1R,2R)-N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimida...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29ClN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258083
PNG
(CHEMBL494183 | N-(2-(4-(5-chloro-2-oxo-2,3-dihydro...)
Show SMILES Cc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Show InChI InChI=1S/C22H25ClN4O2/c1-15-2-4-16(5-3-15)21(28)24-10-13-26-11-8-18(9-12-26)27-20-7-6-17(23)14-19(20)25-22(27)29/h2-7,14,18H,8-13H2,1H3,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87126
PNG
(N-[2-[4-(5-iodanyl-2-oxidanylidene-3H-benzimidazol...)
Show SMILES Ic1ccc2n(C3CCN(CCNC(=O)C4CC4c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C24H27IN4O2/c25-17-6-7-22-21(14-17)27-24(31)29(22)18-8-11-28(12-9-18)13-10-26-23(30)20-15-19(20)16-4-2-1-3-5-16/h1-7,14,18-20H,8-13,15H2,(H,26,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87133
PNG
(N-[(1S)-2-[1-(3-fluorophenyl)-4-keto-1,3,8-triazas...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H29FN4O2/c1-19(30-25(33)22-10-9-20-5-2-3-6-21(20)15-22)17-31-13-11-27(12-14-31)26(34)29-18-32(27)24-8-4-7-23(28)16-24/h2-10,15-16,19H,11-14,17-18H2,1H3,(H,29,34)(H,30,33)/t19-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87218
PNG
(N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87223
PNG
(4-fluoranyl-N-[(2S)-1-[4-(5-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87221
PNG
(N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27ClN4O2/c1-15-3-5-17(6-4-15)22(29)25-16(2)14-27-11-9-19(10-12-27)28-21-8-7-18(24)13-20(21)26-23(28)30/h3-8,13,16,19H,9-12,14H2,1-2H3,(H,25,29)(H,26,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87224
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-[4-(5-fluoranyl-2-oxi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F3N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258130
PNG
(4-fluoro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O
Show InChI InChI=1S/C21H22F2N4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87229
PNG
((1R,2R)-N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimida...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29FN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-13-18(26)7-8-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87130
PNG
(4-chloranyl-N-[(2S)-1-[4-(5-iodanyl-2-oxidanyliden...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(I)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClIN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87242
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)piperidino]et...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cc2ccccc2c2ccccc12
Show InChI InChI=1S/C29H28N4O2/c34-28(25-19-20-7-1-2-8-22(20)23-9-3-4-10-24(23)25)30-15-18-32-16-13-21(14-17-32)33-27-12-6-5-11-26(27)31-29(33)35/h1-12,19,21H,13-18H2,(H,30,34)(H,31,35)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87155
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C26H27F2N5O2/c1-17(31-24(34)19-12-18-4-2-3-5-23(18)29-14-19)15-32-10-8-26(9-11-32)25(35)30-16-33(26)20-6-7-21(27)22(28)13-20/h2-7,12-14,17H,8-11,15-16H2,1H3,(H,30,35)(H,31,34)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87189
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C25H27N5O2/c1-17(27-24(31)19-8-9-21-18(15-19)5-4-12-26-21)16-29-13-10-20(11-14-29)30-23-7-3-2-6-22(23)28-25(30)32/h2-9,12,15,17,20H,10-11,13-14,16H2,1H3,(H,27,31)(H,28,32)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258129
PNG
(4-chloro-N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87200
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-[4-(2-oxidanylidene-3...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-6-7-17(23)18(24)12-15)13-27-10-8-16(9-11-27)28-20-5-3-2-4-19(20)26-22(28)30/h2-7,12,14,16H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87245
PNG
(CHEMBL492797 | ML272 | N-(2-(4-(2-Oxo-2,3-dihydro-...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H26N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-10,17,21H,11-16H2,(H,26,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87128
PNG
(N-[(1S)-2-[4-(5-iodo-2-keto-3H-benzimidazol-1-yl)p...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(I)cc2[nH]c1=O)NC(=O)C1CC1c1ccccc1
Show InChI InChI=1S/C25H29IN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20?,21?/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87199
PNG
(3,4-bis(chloranyl)-N-[(2S)-1-[4-(2-oxidanylidene-3...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14(25-21(29)15-6-7-17(23)18(24)12-15)13-27-10-8-16(9-11-27)28-20-5-3-2-4-19(20)26-22(28)30/h2-7,12,14,16H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87153
PNG
(5-fluoranyl-N-[(2S)-3-methyl-1-(4-oxidanylidene-1-...)
Show SMILES CC(C)[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C27H32FN5O2/c1-18(2)24(31-25(34)23-15-19-14-20(28)8-9-22(19)30-23)16-32-12-10-27(11-13-32)26(35)29-17-33(27)21-6-4-3-5-7-21/h3-9,14-15,18,24,30H,10-13,16-17H2,1-2H3,(H,29,35)(H,31,34)/t24-/m1/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87182
PNG
((1R,2R)-N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimida...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29ClN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87129
PNG
(N-[(1S)-2-[4-(5-iodo-2-keto-3H-benzimidazol-1-yl)p...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(I)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27IN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87156
PNG
(4-chloro-N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClF2N4O2/c1-15(28-21(31)16-2-4-17(24)5-3-16)13-29-10-8-23(9-11-29)22(32)27-14-30(23)18-6-7-19(25)20(26)12-18/h2-7,12,15H,8-11,13-14H2,1H3,(H,27,32)(H,28,31)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87173
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)piperidino]et...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cscn1
Show InChI InChI=1S/C18H21N5O2S/c24-17(15-11-26-12-20-15)19-7-10-22-8-5-13(6-9-22)23-16-4-2-1-3-14(16)21-18(23)25/h1-4,11-13H,5-10H2,(H,19,24)(H,21,25)
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n/an/a 33n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87239
PNG
(N-[(1S)-2-(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]d...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87207
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-[4-(4-fluoranyl-2-oxi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F3N4O2/c1-13(26-21(30)14-5-6-16(23)18(25)11-14)12-28-9-7-15(8-10-28)29-19-4-2-3-17(24)20(19)27-22(29)31/h2-6,11,13,15H,7-10,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258036
PNG
(CHEMBL494007 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)C#Cc1ccccc1
Show InChI InChI=1S/C23H24N4O2/c28-22(11-10-18-6-2-1-3-7-18)24-14-17-26-15-12-19(13-16-26)27-21-9-5-4-8-20(21)25-23(27)29/h1-9,19H,12-17H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87205
PNG
(4-chloranyl-N-[(2S)-1-[4-(4-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-5-7-16(23)8-6-15)13-27-11-9-17(10-12-27)28-19-4-2-3-18(24)20(19)26-22(28)30/h2-8,14,17H,9-13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87246
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)-3,6-dih...)
Show SMILES C[C@@H](CN1CCC(=CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H26N4O2/c1-18(27-25(31)21-11-10-19-6-2-3-7-20(19)16-21)17-29-14-12-22(13-15-29)30-24-9-5-4-8-23(24)28-26(30)32/h2-12,16,18H,13-15,17H2,1H3,(H,27,31)(H,28,32)/t18-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87181
PNG
(N-[(1R)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m1/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87208
PNG
(N-[(1S)-2-[4-(4-fluoro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27FN4O2/c1-17(28-25(32)20-10-9-18-5-2-3-6-19(18)15-20)16-30-13-11-21(12-14-30)31-23-8-4-7-22(27)24(23)29-26(31)33/h2-10,15,17,21H,11-14,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258037
PNG
(CHEMBL494008 | N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H25N5O2/c30-23(18-7-8-20-17(16-18)4-3-11-25-20)26-12-15-28-13-9-19(10-14-28)29-22-6-2-1-5-21(22)27-24(29)31/h1-8,11,16,19H,9-10,12-15H2,(H,26,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87233
PNG
(1-(3-fluorophenyl)-3-[2-[4-(2-keto-3H-benzimidazol...)
Show SMILES Fc1cccc(NC(=O)NCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)c1
Show InChI InChI=1S/C21H24FN5O2/c22-15-4-3-5-16(14-15)24-20(28)23-10-13-26-11-8-17(9-12-26)27-19-7-2-1-6-18(19)25-21(27)29/h1-7,14,17H,8-13H2,(H,25,29)(H2,23,24,28)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87203
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cccnc1
Show InChI InChI=1S/C21H25N5O2/c1-15(23-20(27)16-5-4-10-22-13-16)14-25-11-8-17(9-12-25)26-19-7-3-2-6-18(19)24-21(26)28/h2-7,10,13,15,17H,8-9,11-12,14H2,1H3,(H,23,27)(H,24,28)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87198
PNG
((2R)-N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)pip...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)C1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H30N4O2/c1-17(26-24(30)21-15-20(21)18-7-3-2-4-8-18)16-28-13-11-19(12-14-28)29-23-10-6-5-9-22(23)27-25(29)31/h2-10,17,19-21H,11-16H2,1H3,(H,26,30)(H,27,31)/t17-,20-,21?/m0/s1
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n/an/a 88n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87152
PNG
(N-[(1S)-1-[(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES CC(C)[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C28H33N5O2/c1-20(2)25(31-26(34)22-16-21-8-6-7-11-24(21)29-17-22)18-32-14-12-28(13-15-32)27(35)30-19-33(28)23-9-4-3-5-10-23/h3-11,16-17,20,25H,12-15,18-19H2,1-2H3,(H,30,35)(H,31,34)/t25-/m1/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87134
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H28F2N4O2/c1-18(31-25(34)21-7-6-19-4-2-3-5-20(19)14-21)16-32-12-10-27(11-13-32)26(35)30-17-33(27)22-8-9-23(28)24(29)15-22/h2-9,14-15,18H,10-13,16-17H2,1H3,(H,30,35)(H,31,34)/t18-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87132
PNG
(5-fluoranyl-N-[2-(4-oxidanylidene-1-phenyl-1,3,8-t...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H26FN5O2/c25-18-6-7-20-17(14-18)15-21(28-20)22(31)26-10-13-29-11-8-24(9-12-29)23(32)27-16-30(24)19-4-2-1-3-5-19/h1-7,14-15,28H,8-13,16H2,(H,26,31)(H,27,32)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87209
PNG
((1R,2R)-N-[(1S)-2-[4-(4-fluoro-2-keto-3H-benzimida...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29FN4O2/c1-16(27-24(31)20-14-19(20)17-6-3-2-4-7-17)15-29-12-10-18(11-13-29)30-22-9-5-8-21(26)23(22)28-25(30)32/h2-9,16,18-20H,10-15H2,1H3,(H,27,31)(H,28,32)/t16-,19-,20+/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87157
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H25F3N4O2/c1-15(28-21(31)16-2-4-17(24)5-3-16)13-29-10-8-23(9-11-29)22(32)27-14-30(23)18-6-7-19(25)20(26)12-18/h2-7,12,15H,8-11,13-14H2,1H3,(H,27,32)(H,28,31)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87232
PNG
(1-(3-fluorobenzyl)-3-[2-[4-(2-keto-3H-benzimidazol...)
Show SMILES Fc1cccc(CNC(=O)NCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)c1
Show InChI InChI=1S/C22H26FN5O2/c23-17-5-3-4-16(14-17)15-25-21(29)24-10-13-27-11-8-18(9-12-27)28-20-7-2-1-6-19(20)26-22(28)30/h1-7,14,18H,8-13,15H2,(H,26,30)(H2,24,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87241
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)piperidino]et...)
Show SMILES O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)C1Cc2ccccc2C=C1
Show InChI InChI=1S/C25H28N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-10,20-21H,11-17H2,(H,26,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258082
PNG
(6-fluoro-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Fc1ccc2cc(ccc2c1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H25FN4O2/c26-20-8-7-17-15-19(6-5-18(17)16-20)24(31)27-11-14-29-12-9-21(10-13-29)30-23-4-2-1-3-22(23)28-25(30)32/h1-8,15-16,21H,9-14H2,(H,27,31)(H,28,32)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87204
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O2/c1-15(27-21(31)16-6-8-17(9-7-16)23(24,25)26)14-29-12-10-18(11-13-29)30-20-5-3-2-4-19(20)28-22(30)32/h2-9,15,18H,10-14H2,1H3,(H,27,31)(H,28,32)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87206
PNG
(4-fluoranyl-N-[(2S)-1-[4-(4-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-5-7-16(23)8-6-15)13-27-11-9-17(10-12-27)28-19-4-2-3-18(24)20(19)26-22(28)30/h2-8,14,17H,9-13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87251
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)-3,6-dihydro-...)
Show SMILES O=C(NCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O)C1CC=c2ccccc2=C1
Show InChI InChI=1S/C25H26N4O2/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)26-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)27-25(29)31/h1-9,11,17,20H,10,12-16H2,(H,26,30)(H,27,31)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87150
PNG
(N-[(1S)-1-[(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]...)
Show SMILES CC(C)[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C29H34N4O2/c1-21(2)26(31-27(34)24-13-12-22-8-6-7-9-23(22)18-24)19-32-16-14-29(15-17-32)28(35)30-20-33(29)25-10-4-3-5-11-25/h3-13,18,21,26H,14-17,19-20H2,1-2H3,(H,30,35)(H,31,34)/t26-/m1/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87240
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-(4-oxidanylidene-1-ph...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H26F2N4O2/c1-16(27-21(30)17-7-8-19(24)20(25)13-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)18-5-3-2-4-6-18/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87188
PNG
(CHEMBL471257 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)
Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cc2ccccc2s1
Show InChI InChI=1S/C24H26N4O2S/c29-22(21-16-18-6-4-5-9-20(18)31-21)25-12-15-27-13-10-24(11-14-27)23(30)26-17-28(24)19-7-2-1-3-8-19/h1-9,16H,10-15,17H2,(H,25,29)(H,26,30)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87202
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccco1
Show InChI InChI=1S/C20H24N4O3/c1-14(21-19(25)18-7-4-12-27-18)13-23-10-8-15(9-11-23)24-17-6-3-2-5-16(17)22-20(24)26/h2-7,12,14-15H,8-11,13H2,1H3,(H,21,25)(H,22,26)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87172
PNG
(6-fluoranyl-N-[2-[4-(2-oxidanylidene-3H-benzimidaz...)
Show SMILES Fc1cccc(n1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H22FN5O2/c21-18-7-3-5-16(23-18)19(27)22-10-13-25-11-8-14(9-12-25)26-17-6-2-1-4-15(17)24-20(26)28/h1-7,14H,8-13H2,(H,22,27)(H,24,28)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87248
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)-3,6-dihydro-...)
Show SMILES O=C(NCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O)C1CC1c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c29-23(20-16-19(20)17-6-2-1-3-7-17)25-12-15-27-13-10-18(11-14-27)28-22-9-5-4-8-21(22)26-24(28)30/h1-10,19-20H,11-16H2,(H,25,29)(H,26,30)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87244
PNG
(4-chloranyl-N-(4-chlorophenyl)carbonyl-N-[2-[4-(2-...)
Show SMILES Clc1ccc(cc1)C(=O)N(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H26Cl2N4O3/c29-21-9-5-19(6-10-21)26(35)33(27(36)20-7-11-22(30)12-8-20)18-17-32-15-13-23(14-16-32)34-25-4-2-1-3-24(25)31-28(34)37/h1-12,23H,13-18H2,(H,31,37)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87177
PNG
(5-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H25F2N5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87210
PNG
(N-[(1S)-2-[4-(4-fluoro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cccc(F)c2[nH]c1=O)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27FN4O2/c1-15-6-8-17(9-7-15)22(29)25-16(2)14-27-12-10-18(11-13-27)28-20-5-3-4-19(24)21(20)26-23(28)30/h3-9,16,18H,10-14H2,1-2H3,(H,25,29)(H,26,30)/t16-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87148
PNG
(CHEMBL1254908 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25ClFN5O2/c25-17-2-1-3-19(14-17)31-15-28-23(33)24(31)6-9-30(10-7-24)11-8-27-22(32)21-13-16-12-18(26)4-5-20(16)29-21/h1-5,12-14,29H,6-11,15H2,(H,27,32)(H,28,33)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87191
PNG
(3-(4-fluorophenyl)-N-[(1S)-2-[4-(2-keto-3H-benzimi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)CCc1ccc(F)cc1
Show InChI InChI=1S/C24H29FN4O2/c1-17(26-23(30)11-8-18-6-9-19(25)10-7-18)16-28-14-12-20(13-15-28)29-22-5-3-2-4-21(22)27-24(29)31/h2-7,9-10,17,20H,8,11-16H2,1H3,(H,26,30)(H,27,31)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87243
PNG
(3,5-dinitro-N-[2-[4-(2-oxidanylidene-3H-benzimidaz...)
Show SMILES [O-][N+](=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O6/c28-20(14-11-16(26(30)31)13-17(12-14)27(32)33)22-7-10-24-8-5-15(6-9-24)25-19-4-2-1-3-18(19)23-21(25)29/h1-4,11-13,15H,5-10H2,(H,22,28)(H,23,29)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87166
PNG
(5-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1
Show InChI InChI=1S/C24H25F2N5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)
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Vanderbilt Specialized Chemistry Center

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Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87176
PNG
(4,5-bis(bromanyl)-N-[(2R)-1-(4-oxidanylidene-1-phe...)
Show SMILES C[C@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cc(Br)c(Br)o1
Show InChI InChI=1S/C21H24Br2N4O3/c1-14(25-19(28)17-11-16(22)18(23)30-17)12-26-9-7-21(8-10-26)20(29)24-13-27(21)15-5-3-2-4-6-15/h2-6,11,14H,7-10,12-13H2,1H3,(H,24,29)(H,25,28)/t14-/m1/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87142
PNG
(CHEMBL1254081 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClFN5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)
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n/an/a 335n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87137
PNG
(CHEMBL1255081 | N-[2-[1-(3,4-difluorophenyl)-4-ket...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C24H24F3N5O2/c25-16-1-4-20-15(11-16)12-21(30-20)22(33)28-7-10-31-8-5-24(6-9-31)23(34)29-14-32(24)17-2-3-18(26)19(27)13-17/h1-4,11-13,30H,5-10,14H2,(H,28,33)(H,29,34)
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n/an/a 390n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87180
PNG
(4-fluoranyl-N-[(2R)-1-(4-oxidanylidene-1-phenyl-1,...)
Show SMILES C[C@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H27FN4O2/c1-17(26-21(29)18-7-9-19(24)10-8-18)15-27-13-11-23(12-14-27)22(30)25-16-28(23)20-5-3-2-4-6-20/h2-10,17H,11-16H2,1H3,(H,25,30)(H,26,29)/t17-/m1/s1
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n/an/a 413n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87247
PNG
((1S,2S)-N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(=CC1)n1c2ccccc2[nH]c1=O)NC(=O)[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C25H28N4O2/c1-17(26-24(30)21-15-20(21)18-7-3-2-4-8-18)16-28-13-11-19(12-14-28)29-23-10-6-5-9-22(23)27-25(29)31/h2-11,17,20-21H,12-16H2,1H3,(H,26,30)(H,27,31)/t17-,20+,21-/m0/s1
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n/an/a 480n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87146
PNG
(CHEMBL1254822 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...)
Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26ClN5O2/c26-20-5-3-6-21(15-20)31-17-29-24(33)25(31)8-11-30(12-9-25)13-10-27-23(32)19-14-18-4-1-2-7-22(18)28-16-19/h1-7,14-16H,8-13,17H2,(H,27,32)(H,29,33)
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n/an/a 870n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87145
PNG
(CHEMBL1254737 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...)
Show SMILES Clc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27ClN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87154
PNG
(N-[2-[4-(2-keto-3-methyl-benzimidazol-1-yl)piperid...)
Show SMILES Cn1c2ccccc2n(C2CCN(CCNC(=O)c3ccc4ccccc4c3)CC2)c1=O
Show InChI InChI=1S/C26H28N4O2/c1-28-23-8-4-5-9-24(23)30(26(28)32)22-12-15-29(16-13-22)17-14-27-25(31)21-11-10-19-6-2-3-7-20(19)18-21/h2-11,18,22H,12-17H2,1H3,(H,27,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87120
PNG
(CHEMBL1254577 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87163
PNG
(CHEMBL1255082 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27FN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87231
PNG
(N-[2-(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]decan-...)
Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cnc2ccccc2c1
Show InChI InChI=1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87164
PNG
(CHEMBL1253820 | N-[2-[1-(4-fluorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26FN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87124
PNG
(N-[2-[4-(2-keto-3H-benzimidazol-1-yl)piperidino]et...)
Show SMILES CN(CCN1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N4O2/c1-28(25(31)21-11-10-19-6-2-3-7-20(19)18-21)16-17-29-14-12-22(13-15-29)30-24-9-5-4-8-23(24)27-26(30)32/h2-11,18,22H,12-17H2,1H3,(H,27,32)
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n/an/a 2.06E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87160
PNG
(CHEMBL1254996 | N-[2-[1-(3,4-difluorophenyl)-4-ket...)
Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H25F2N5O2/c26-20-6-5-19(14-21(20)27)32-16-30-24(34)25(32)7-10-31(11-8-25)12-9-28-23(33)18-13-17-3-1-2-4-22(17)29-15-18/h1-6,13-15H,7-12,16H2,(H,28,33)(H,30,34)
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n/an/a 2.06E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87186
PNG
(CHEMBL471055 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)
Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C#Cc1ccccc1
Show InChI InChI=1S/C24H26N4O2/c29-22(12-11-20-7-3-1-4-8-20)25-15-18-27-16-13-24(14-17-27)23(30)26-19-28(24)21-9-5-2-6-10-21/h1-10H,13-19H2,(H,25,29)(H,26,30)
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n/an/a 2.13E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87138
PNG
(CHEMBL1253901 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...)
Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27ClN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)
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n/an/a 2.27E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87136
PNG
(4-chloro-N-[2-[1-(3,4-difluorophenyl)-4-keto-1,3,8...)
Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H23ClF2N4O2/c23-16-3-1-15(2-4-16)20(30)26-9-12-28-10-7-22(8-11-28)21(31)27-14-29(22)17-5-6-18(24)19(25)13-17/h1-6,13H,7-12,14H2,(H,26,30)(H,27,31)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87184
PNG
(CHEMBL1254653 | N-[2-[1-(3-fluorophenyl)-4-keto-1,...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26FN5O2/c26-20-5-3-6-21(15-20)31-17-29-24(33)25(31)8-11-30(12-9-25)13-10-27-23(32)19-14-18-4-1-2-7-22(18)28-16-19/h1-7,14-16H,8-13,17H2,(H,27,32)(H,29,33)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87238
PNG
((1R,2R)-N-[(1S)-2-(4-keto-1-phenyl-1,3,8-triazaspi...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C26H32N4O2/c1-19(28-24(31)23-16-22(23)20-8-4-2-5-9-20)17-29-14-12-26(13-15-29)25(32)27-18-30(26)21-10-6-3-7-11-21/h2-11,19,22-23H,12-18H2,1H3,(H,27,32)(H,28,31)/t19-,22-,23+/m0/s1
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n/an/a 2.56E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87170
PNG
(CHEMBL1254176 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Br)cc1
Show InChI InChI=1S/C24H25BrFN5O2/c25-17-1-4-19(5-2-17)31-15-28-23(33)24(31)7-10-30(11-8-24)12-9-27-22(32)21-14-16-13-18(26)3-6-20(16)29-21/h1-6,13-14,29H,7-12,15H2,(H,27,32)(H,28,33)
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n/an/a 2.66E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87168
PNG
(CHEMBL1254576 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...)
Show SMILES Brc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26BrN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87249
PNG
(N-[2-[4-(1-benzotriazolyl)-1-piperidinyl]ethyl]-2-...)
Show SMILES O=C(NCCN1CCC(CC1)n1nnc2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H25N5O/c30-24(20-10-9-18-5-1-2-6-19(18)17-20)25-13-16-28-14-11-21(12-15-28)29-23-8-4-3-7-22(23)26-27-29/h1-10,17,21H,11-16H2,(H,25,30)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87162
PNG
(N-[2-(3-methyl-4-oxidanylidene-1-phenyl-1,3,8-tria...)
Show SMILES CN1CN(c2ccccc2)C2(CCN(CCNC(=O)c3ccc4ccccc4c3)CC2)C1=O
Show InChI InChI=1S/C27H30N4O2/c1-29-20-31(24-9-3-2-4-10-24)27(26(29)33)13-16-30(17-14-27)18-15-28-25(32)23-12-11-21-7-5-6-8-22(21)19-23/h2-12,19H,13-18,20H2,1H3,(H,28,32)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87197
PNG
(3-[1-[(1-quinolin-3-ylcarbonylpyrrolidin-2-yl)meth...)
Show SMILES O=C(N1CCCC1CN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cnc2ccccc2c1
Show InChI InChI=1S/C27H29N5O2/c33-26(20-16-19-6-1-2-8-23(19)28-17-20)31-13-5-7-22(31)18-30-14-11-21(12-15-30)32-25-10-4-3-9-24(25)29-27(32)34/h1-4,6,8-10,16-17,21-22H,5,7,11-15,18H2,(H,29,34)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87196
PNG
(N-[(1S)-1-benzyl-2-[4-(2-keto-3H-benzimidazol-1-yl...)
Show SMILES O=C(N[C@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)Cc1ccccc1)c1cnc2ccccc2c1
Show InChI InChI=1S/C31H31N5O2/c37-30(24-19-23-10-4-5-11-27(23)32-20-24)33-25(18-22-8-2-1-3-9-22)21-35-16-14-26(15-17-35)36-29-13-7-6-12-28(29)34-31(36)38/h1-13,19-20,25-26H,14-18,21H2,(H,33,37)(H,34,38)/t25-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87135
PNG
(CHEMBL1254909 | N-[2-[1-(3,4-difluorophenyl)-4-ket...)
Show SMILES Fc1ccc(cc1F)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H26F2N4O2/c27-22-8-7-21(16-23(22)28)32-17-30-25(34)26(32)9-12-31(13-10-26)14-11-29-24(33)20-6-5-18-3-1-2-4-19(18)15-20/h1-8,15-16H,9-14,17H2,(H,29,33)(H,30,34)
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n/an/a 2.81E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87237
PNG
(3-methyl-N-[(2S)-1-(4-oxidanylidene-1-phenyl-1,3,8...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cccc(C)c1
Show InChI InChI=1S/C24H30N4O2/c1-18-7-6-8-20(15-18)22(29)26-19(2)16-27-13-11-24(12-14-27)23(30)25-17-28(24)21-9-4-3-5-10-21/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,25,30)(H,26,29)/t19-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87147
PNG
(CHEMBL1254823 | N-[2-[1-(3-chlorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H24ClFN4O2/c23-17-2-1-3-19(14-17)28-15-26-21(30)22(28)8-11-27(12-9-22)13-10-25-20(29)16-4-6-18(24)7-5-16/h1-7,14H,8-13,15H2,(H,25,29)(H,26,30)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87139
PNG
(CHEMBL1253988 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...)
Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26ClN5O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87140
PNG
(4-chloranyl-N-[2-[1-(4-chlorophenyl)-4-oxidanylide...)
Show SMILES Clc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C22H24Cl2N4O2/c23-17-3-1-16(2-4-17)20(29)25-11-14-27-12-9-22(10-13-27)21(30)26-15-28(22)19-7-5-18(24)6-8-19/h1-8H,9-15H2,(H,25,29)(H,26,30)
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n/an/a 3.59E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87234
PNG
(5-fluoranyl-N-[2-(4-pyridin-4-ylpiperazin-1-yl)eth...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NCCN1CCN(CC1)c1ccncc1
Show InChI InChI=1S/C20H22FN5O/c21-16-1-2-18-15(13-16)14-19(24-18)20(27)23-7-8-25-9-11-26(12-10-25)17-3-5-22-6-4-17/h1-6,13-14,24H,7-12H2,(H,23,27)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87250
PNG
(N-[(1R)-2-[4-(benzotriazol-1-yl)piperidino]-1-meth...)
Show SMILES C[C@H](CN1CCC(CC1)n1nnc2ccccc12)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H27N5O/c1-18(26-25(31)21-11-10-19-6-2-3-7-20(19)16-21)17-29-14-12-22(13-15-29)30-24-9-5-4-8-23(24)27-28-30/h2-11,16,18,22H,12-15,17H2,1H3,(H,26,31)/t18-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87187
PNG
(CHEMBL471258 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)
Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C1CCc2ccccc2C1
Show InChI InChI=1S/C26H32N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-9,22H,10-19H2,(H,27,31)(H,28,32)
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n/an/a 4.25E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87149
PNG
(N-[2-[1-(3-bromophenyl)-4-keto-1,3,8-triazaspiro[4...)
Show SMILES Brc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27BrN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87122
PNG
(N-[2-[1-(3-fluorophenyl)-4-keto-1,3,8-triazaspiro[...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3C(=O)OC(=O)c3c2)CC1
Show InChI InChI=1S/C24H23FN4O5/c25-16-2-1-3-17(13-16)29-14-27-23(33)24(29)6-9-28(10-7-24)11-8-26-20(30)15-4-5-18-19(12-15)22(32)34-21(18)31/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,33)
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n/an/a 5.55E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87141
PNG
(CHEMBL1253989 | N-[2-[1-(4-chlorophenyl)-4-keto-1,...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c23-17-3-7-19(8-4-17)28-15-26-21(30)22(28)9-12-27(13-10-22)14-11-25-20(29)16-1-5-18(24)6-2-16/h1-8H,9-15H2,(H,25,29)(H,26,30)
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n/an/a 5.59E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87171
PNG
(N-[(1S)-1-[[4-(2-keto-3H-benzimidazol-1-yl)piperid...)
Show SMILES CC(C)[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C28H32N4O2/c1-19(2)25(29-27(33)22-12-11-20-7-3-4-8-21(20)17-22)18-31-15-13-23(14-16-31)32-26-10-6-5-9-24(26)30-28(32)34/h3-12,17,19,23,25H,13-16,18H2,1-2H3,(H,29,33)(H,30,34)/t25-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87161
PNG
(CHEMBL1254997 | N-[2-[1-(3,4-difluorophenyl)-4-ket...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F3N4O2/c23-16-3-1-15(2-4-16)20(30)26-9-12-28-10-7-22(8-11-28)21(31)27-14-29(22)17-5-6-18(24)19(25)13-17/h1-6,13H,7-12,14H2,(H,26,30)(H,27,31)
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n/an/a 5.78E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87185
PNG
(4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triaz...)
Show SMILES COc1cc(ccc1N)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H29N5O3/c1-31-20-15-17(7-8-19(20)24)21(29)25-11-14-27-12-9-23(10-13-27)22(30)26-16-28(23)18-5-3-2-4-6-18/h2-8,15H,9-14,16,24H2,1H3,(H,25,29)(H,26,30)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87167
PNG
(CHEMBL1254082 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...)
Show SMILES Brc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H27BrN4O2/c27-22-7-9-23(10-8-22)31-18-29-25(33)26(31)11-14-30(15-12-26)16-13-28-24(32)21-6-5-19-3-1-2-4-20(19)17-21/h1-10,17H,11-16,18H2,(H,28,32)(H,29,33)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87235
PNG
(N-[2-[4-(3-methoxyphenyl)-1-piperazinyl]ethyl]-2-n...)
Show SMILES COc1cccc(c1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H27N3O2/c1-29-23-8-4-7-22(18-23)27-15-13-26(14-16-27)12-11-25-24(28)21-10-9-19-5-2-3-6-20(19)17-21/h2-10,17-18H,11-16H2,1H3,(H,25,28)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87169
PNG
(CHEMBL1254175 | N-[2-[1-(4-bromophenyl)-4-keto-1,3...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccc(Br)cc1
Show InChI InChI=1S/C22H24BrFN4O2/c23-17-3-7-19(8-4-17)28-15-26-21(30)22(28)9-12-27(13-10-22)14-11-25-20(29)16-1-5-18(24)6-2-16/h1-8H,9-15H2,(H,25,29)(H,26,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87131
PNG
(4-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1
Show InChI InChI=1S/C22H24F2N4O2/c23-17-6-4-16(5-7-17)20(29)25-10-13-27-11-8-22(9-12-27)21(30)26-15-28(22)19-3-1-2-18(24)14-19/h1-7,14H,8-13,15H2,(H,25,29)(H,26,30)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87174
PNG
(6-fluoranyl-N-[2-(4-oxidanylidene-1-phenyl-1,3,8-t...)
Show SMILES Fc1cccc(n1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C21H24FN5O2/c22-18-8-4-7-17(25-18)19(28)23-11-14-26-12-9-21(10-13-26)20(29)24-15-27(21)16-5-2-1-3-6-16/h1-8H,9-15H2,(H,23,28)(H,24,29)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87165
PNG
(4-fluoranyl-N-[2-[1-(4-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1ccc(cc1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H24F2N4O2/c23-17-3-1-16(2-4-17)20(29)25-11-14-27-12-9-22(10-13-27)21(30)26-15-28(22)19-7-5-18(24)6-8-19/h1-8H,9-15H2,(H,25,29)(H,26,30)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87178
PNG
(6-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)nc2)CC1
Show InChI InChI=1S/C21H23F2N5O2/c22-16-2-1-3-17(12-16)28-14-26-20(30)21(28)6-9-27(10-7-21)11-8-24-19(29)15-4-5-18(23)25-13-15/h1-5,12-13H,6-11,14H2,(H,24,29)(H,26,30)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87144
PNG
(N-(cyclopropylmethyl)-1-[2-(2-naphthoylamino)ethyl...)
Show SMILES O=C(NCC1CC1)C1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C23H29N3O2/c27-22(25-16-17-5-6-17)19-9-12-26(13-10-19)14-11-24-23(28)21-8-7-18-3-1-2-4-20(18)15-21/h1-4,7-8,15,17,19H,5-6,9-14,16H2,(H,24,28)(H,25,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87175
PNG
(3,5-bis(fluoranyl)-N-[2-(4-oxidanylidene-1-phenyl-...)
Show SMILES Fc1cnc(C(=O)NCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C21H23F2N5O2/c22-15-12-17(23)18(25-13-15)19(29)24-8-11-27-9-6-21(7-10-27)20(30)26-14-28(21)16-4-2-1-3-5-16/h1-5,12-13H,6-11,14H2,(H,24,29)(H,26,30)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87123
PNG
(3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxid...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1
Show InChI InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87194
PNG
(N-[2-(1-keto-2-phenyl-2,8-diazaspiro[4.5]decan-8-y...)
Show SMILES O=C(NCCN1CCC2(CCN(C2=O)c2ccccc2)CC1)c1cnc2ccccc2c1
Show InChI InChI=1S/C26H28N4O2/c31-24(21-18-20-6-4-5-9-23(20)28-19-21)27-13-17-29-14-10-26(11-15-29)12-16-30(25(26)32)22-7-2-1-3-8-22/h1-9,18-19H,10-17H2,(H,27,31)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87125
PNG
(N-[2-(4-keto-1-phenyl-1,3,8-triazaspiro[4.5]decan-...)
Show SMILES CN(CCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C27H30N4O2/c1-29(25(32)23-12-11-21-7-5-6-8-22(21)19-23)17-18-30-15-13-27(14-16-30)26(33)28-20-31(27)24-9-3-2-4-10-24/h2-12,19H,13-18,20H2,1H3,(H,28,33)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87143
PNG
(1-[2-(2-naphthoylamino)ethyl]-N-[2-(2-pyridyl)ethy...)
Show SMILES O=C(NCCc1ccccn1)C1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H30N4O2/c31-25(28-14-10-24-7-3-4-13-27-24)21-11-16-30(17-12-21)18-15-29-26(32)23-9-8-20-5-1-2-6-22(20)19-23/h1-9,13,19,21H,10-12,14-18H2,(H,28,31)(H,29,32)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87195
PNG
(N-[2-(2-ketospiro[coumaran-3,4'-piperidine]-1'-yl)...)
Show SMILES O=C(NCCN1CCC2(CC1)C(=O)Oc1ccccc21)c1cnc2ccccc2c1
Show InChI InChI=1S/C24H23N3O3/c28-22(18-15-17-5-1-3-7-20(17)26-16-18)25-11-14-27-12-9-24(10-13-27)19-6-2-4-8-21(19)30-23(24)29/h1-8,15-16H,9-14H2,(H,25,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87121
PNG
(3-fluoranyl-N-[2-[1-(3-fluorophenyl)-4-oxidanylide...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2cccc(F)c2)CC1
Show InChI InChI=1S/C22H24F2N4O2/c23-17-4-1-3-16(13-17)20(29)25-9-12-27-10-7-22(8-11-27)21(30)26-15-28(22)19-6-2-5-18(24)14-19/h1-6,13-14H,7-12,15H2,(H,25,29)(H,26,30)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2NK3CNK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%