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Cell Reactant:DNA Gyrase
Syringe Reactant:BDBM282
Meas. Tech.:Isothermal Titration Calorimetry
Entry Date:03/31/03
 
ΔG°:-10.2±0.120 (kcal/mole)
pH:7.5±n/a
Log10Kb:7.45± 6.90
Temperature:298.15±n/a (K)
ΔH° :-12.4±1 (kcal/mole)
ΔHobs :-12.4±1 (kcal/mole)
Ionic Strength:n/a
Corrected for ΔHioniz:not known
Protons Released:n/a
ΔCp :-0.29±n/a (kcal/mole)
Stoich. Param.:n/a
ΔS° :-0.0100±0 (kcal/mole-K)
Comments:n/a
 
Citation Lafitte, DLamour, VTsvetkov, POMakarov, AAKlich, MDeprez, PMoras, DBriand, CGilli, R DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry41:7217-23 (2002) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info ,  Data Fit Method ,  Instrument Info
 
DNA Gyrase
Source:Bacterial clone
Purity:97%
Prep. Method:n/a
Name:DNA Gyrase
Synonyms:n/a
Type:Enzyme
Mol. Mass.:38989.92
Organism:Escherichia coli
Description:A0A0C2BP49
Residue:354
Sequence:
MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM282
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM282
Synonyms:(3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzene]amido}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyloxan-4-yl carbamate | Coumarin-Based, DNA Gyrase Inhibitor | Novobiocin
TypeAntibiotic
Emp. Form.C31H36N2O11
Mol. Mass.612.6243
SMILES[#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@@H](-[#8])-[#6@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6] |r|
Structure
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Last update November 1, 2007
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