Cell Reactant:
Histone deacetylase 8 (HDAC8)
Syringe Reactant:
BDBM152690
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
09/14/15
ΔG°:
-8.61±0.19 (kcal/mole)
pH:
7.5±0
Temperature:
25±0 (K)
ΔH° :
-11.72±n/a (kJ/mole)
ΔHobs :
-5.5±0.48 (kJ/mole)
ΔS° :
-0.01±0 (kJ/mole-K)
Citation
 Singh, RKSuzuki, TMandal, TBalsubramanian, NHaldar, MMueller, DJStrode, JACook, GMallik, SSrivastava, DK Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. Biochemistry 53:7445-58 (2014) [PubMed]  Article
Cell React
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Syringe React
Name:
BDBM152690
Synonyms:
C6-coumarinSAHA (C6-cSAHA)
Type:
Small organic molecule
Emp. Form.:
C18H22N2O5
Mol. Mass.:
346.3777
SMILES:
Cc1cc(=O)oc2cc(NC(=O)CCCCCCC(=O)NO)ccc12
Structure:
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