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Cell Reactant:Bromodomain-containing protein 4 (BRD4)
Syringe Reactant:BDBM205431
Meas. Tech.:Enzyme Inhibition
Entry Date:12/15/16
 
ΔG°:-44.4± (kJ/mole)
pH:n/a
Log10Kb:7.79± n/a
Temperature:298.15±0 (K)
ΔH° :-41.4±0.896 (kJ/mole)
ΔHobs:n/a
Ionic Strength:n/a
Corrected for ΔHioniz:n/a
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° : 0.0103±0 (kJ/mole-K)
Comments:n/a
 
Citation Tanaka, MRoberts, JMSeo, HSSouza, APaulk, JScott, TGDeAngelo, SLDhe-Paganon, SBradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol12:1089-1096 (2016) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data
 
Bromodomain-containing protein 4 (BRD4)
Source:n/a
Purity:n/a
Prep. Method:n/a
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:BET bromodomain 4(1) (BRD4(1)) | BRD4-BD1 protein (aa 44-168) | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1)
Type:Enzyme Catalytic Domain
Mol. Mass.:14866.49
Organism:Homo sapiens (Human)
Description:aa (44-168)
Residue:125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM205431
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM205431
Synonyms:(6S+2S)-PEG1 (7)
TypeSmall organic molecule
Emp. Form.C43H42Cl2N10O5S2
Mol. Mass.913.894
SMILESCOC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,36|
Structure
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