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TargetProtein cereblon
LigandBDBM65454
Substrate/Competitorn/a
Meas. Tech.Thalidomide analog bead assay
IC50 2000±0 nM
Citation Lopez-Girona, AMendy, DIto, TMiller, KGandhi, AKKang, JKarasawa, SCarmel, GJackson, PAbbasian, MMahmoudi, ACathers, BRychak, EGaidarova, SChen, RSchafer, PHHanda, HDaniel, TOEvans, JFChopra, R Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia26:2326-35 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein cereblon
Name:Protein cereblon
Synonyms:CRBN | Protein cereblon
Type:PROTEIN
Mol. Mass.:50537.73
Organism:Homo sapiens (Human)
Description:ChEMBL_116917
Residue:442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
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  Blast E-value cutoff:
BDBM65454
NameBDBM65454
Synonyms:191732-72-6 | CC-5013 | Lenalidomide | Revimid | Revlimid | US9694015, 6.1
TypeSmall organic molecule
Emp. Form.C13H13N3O3
Mol. Mass.259.2606
SMILESNc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a