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Target
Carboxypeptidase B2
Ligand
BDBM173923
Substrate
n/a
Meas. Tech.
TAFI Activity Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
12±n/a nM
Comments
extracted
Citation
 Kallus, C; Broenstrup, M; Evers, A; Globisch, A; Schreuder, H; Wagner, M Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa US Patent  US9688645 Publication Date 6/27/2017 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM173923
Synonyms:
US9688645, 6-3
Type:
Small organic molecule
Emp. Form.:
C27H36FN5O6
Mol. Mass.:
545.603
SMILES:
CC(C)[C@H]1COCCCCOc2ccc(C[C@@H](NC(=O)N[C@@H](Cc3ccc(N)nc3)C(O)=O)C(=O)N1)cc2F |r|
Structure:
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