Reaction Details Report a problem with these data
Target
Casein kinase I isoform delta
Ligand
BDBM302475
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<10±n/a nM
Citation
Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent US9598423 Publication Date 3/21/2017
More Info.:
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
Inhibitor
Name:
BDBM302475
Synonyms:
2-(3-Fluorophenyl)-N5-(3- hydroxyadamantan-1-yl)- 6,7-dihydropyrazolo[1,5- a]pyrazine-3,5(4H)- dicarboxamide | US9598423, Example 41
Type:
Small organic molecule
Emp. Form.:
C24H28FN5O3
Mol. Mass.:
453.5092
SMILES:
NC(=O)c1c2CN(CCn2nc1-c1cccc(F)c1)C(=O)NC12CC3CC(CC(O)(C3)C1)C2 |TLB:25:26:31:23.24.30,30:24:32:31.28.27,30:28:23.24.25:32,27:26:23:31.28.30,27:28:23:25.26.32,THB:29:28:23.24.25:32,25:24:31:26.32.27|