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TargetCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
LigandBDBM168128
Substrate/Competitorn/a
Ki 4.00±n/a nM
Citation Li, PZheng, HZhao, JWennogle, L Organic compounds US Patent US9598426 Publication Date 3/21/2017
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Name:Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Synonyms:63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B)
Type:Enzyme
Mol. Mass.:61366.51
Organism:Homo sapiens (Human)
Description:n/a
Residue:536
Sequence:
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM168128
NameBDBM168128
Synonyms:US9073936, 3 | US9598426, 3
TypeSmall organic molecule
Emp. Form.C25H24F2N6O2
Mol. Mass.478.4939
SMILESCN1C2=NC(C)(C)CN2c2nn(Cc3ccc(cc3)C(C)=O)c(Nc3ccc(F)c(F)c3)c2C1=O |t:2|
Structure
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n/a