Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [861-1152]
Ligand
BDBM174027
Substrate
n/a
Meas. Tech.
JAK1 Kinase Assay
IC50
53±n/a nM
Citation
 Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent  US9688661 Publication Date 6/27/2017 
Target
Name:
Tyrosine-protein kinase JAK1 [861-1152]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Type:
Protein
Mol. Mass.:
33439.94
Organism:
Homo sapiens (Human)
Description:
Human JAK1 variant (861-1152 aa)
Residue:
292
Sequence:
PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
  
Inhibitor
Name:
BDBM174027
Synonyms:
US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxamide (compd 256)
Type:
Small organic molecule
Emp. Form.:
C18H16F3N5O
Mol. Mass.:
375.3477
SMILES:
CCc1ccc(cc1-c1cn(cc1C(N)=O)-c1cc(N)ncn1)C(F)(F)F
Structure:
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