Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM302913
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
190±n/a nM
Citation
 Seganish, WM; McElroy, WT; Brumfield, S; Herr, RJ; Yet, L; Yang, J; Harding, III, JP; Ho, GD; Tulshian, D; Yu, W; Wong, MK; Lavey, B; Kozlowski, JA Inhibitors of IRAK4 activity US Patent  US9598440 Publication Date 3/21/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM302913
Synonyms:
US9598440, 51
Type:
Small organic molecule
Emp. Form.:
C21H26N6O3S
Mol. Mass.:
442.535
SMILES:
OC[C@H]1C[C@@H](Nc2nc(NC3CCNC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: