Target
Complement factor D
Ligand
BDBM303030
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
 Gadhachanda, VRHashimoto, APais, GWang, QChen, DWang, XAgarwal, ADeshpande, MWiles, JAPhadke, AS Amino compounds for treatment of complement mediated disorders US Patent  US9598446 Publication Date 3/21/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM303030
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-4-fluoro-N- (2,2,6- trifluorobenzo[d][1,3] dioxol-5- yl)pyrrolidine-2- carboxamide | US10660876, Cmpd No. 35 | US9598446, Compound 35
Type:
Small organic molecule
Emp. Form.:
C28H22F4N6O5
Mol. Mass.:
598.5051
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cc3OC(F)(F)Oc3cc2F)c2ccc(Nc3cncnc3)cc12 |r|
Structure:
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