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Target
Sphingosine kinase 1
Ligand
BDBM174096
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
55000±n/a nM
Citation
 Santos, WL; Lynch, KR; Macdonald, TL; Kennedy, A; Kharel, Y; Raje, MR; Houck, J Long chain base sphingosine kinase inhibitors US Patent  US9688668 Publication Date 6/27/2017 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM174096
Synonyms:
US9688668, 52
Type:
Small organic molecule
Emp. Form.:
C21H31N5O2
Mol. Mass.:
385.5031
SMILES:
CCCCCCCCc1ccc(cc1)-c1noc(n1)[C@@H]1[C@@H](O)CCN1C(N)=N |r|
Structure:
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