Reaction Details Report a problem with these data
Target
Pgap1 family protein
Ligand
BDBM303816
Substrate
n/a
Meas. Tech.
LCAT Activity Measurement (In Vitro)
EC50
4.00±n/a nM
Citation
 Kobayashi, K; Kaneko, T Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative US Patent  US10138240 Publication Date 11/27/2018 
Target
Name:
Pgap1 family protein
Synonyms:
Acetyltransferase | Lecithin:cholesterol acyltransferase | Pgap1 family protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35510.39
Organism:
Bacillus cereus
Description:
n/a
Residue:
312
Sequence:
MRKGKTPIVFVPGLFGSMNNIIIPGTGDWSFGLSAFVYEPFILMLESMGYERNKNLFICFYDWRQRIIFSTQKYLLQTIAYAKKITGRDKLNLICHSMGGLLGRSYVQSEEYKNDVNQLIILCTPSAGSPANYSYWTGGSLPVHASSKINIVHFYMEQYIHYLSTLYKMNTVEAIHLYFPGLQDVIPCKDYGNYLFIKSGSSITFIPYSKMKTKNPFLDNLNKNRFMIQKRNIETTLIAGDGEETIQYLQVVPSYSSLKWTDGKVVGDMLTKHGDGNAILHSVFLLEGNKCVVHASHNEVLYKSIPILQKIL
  
Inhibitor
Name:
BDBM303816
Synonyms:
(+)-4,5-Dihydroxy-4-(trifluoromethyl)-3-{1-[5-(trifluoromethyl)pyrazin-2-yl]piperidin-4-yl}-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one | US10138240, Example 1
Type:
Small organic molecule
Emp. Form.:
C26H32N4O2
Mol. Mass.:
432.5579
SMILES:
CC(C)(C)OC(=O)N1CCC(CC1)c1cc(N)n(n1)C(c1ccccc1)c1ccccc1
Structure:
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