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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM303821
Substrate
n/a
Meas. Tech.
V9103X ADP-Glo Kinase Assay
IC50
3.50±n/a nM
Citation
 Liu, P; Miller, CA; Yu, M; Zhang, Z; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent  US10138241 Publication Date 11/27/2018 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM303821
Synonyms:
US10138241, Example 5 | US11130754, Example 5
Type:
Small organic molecule
Emp. Form.:
C20H15ClFN5O
Mol. Mass.:
395.817
SMILES:
Fc1cc(Cl)c(cc1C(=O)NC1CC1)-c1cnn(c1)-c1cnc2ccccn12
Structure:
Search PDB for entries with ligand similarity: