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Target
PEX5-related protein/Peroxisomal membrane protein PEX14
Ligand
BDBM303929
Substrate
n/a
Meas. Tech.
Antitrypanosomal Activity Assay
IC50
1090±n/a nM
Citation
 Sattler, M; Popowicz, G; Dawidowski, M; Emmanouilidis, L; Erdmann, R; Schliebs, W; Kalel, V Pyrazolopyridine derivatives and their use in therapy US Patent  US10138242 Publication Date 11/27/2018 
Target
Name:
PEX5-related protein/Peroxisomal membrane protein PEX14
Synonyms:
PEX14-PEX5
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Peroxisomal membrane protein PEX14
Synonyms:
PEX14 | PEX14_HUMAN | PTS1 receptor-docking protein | Peroxin-14 | Peroxisomal membrane anchor protein PEX14
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41218.98
Organism:
Homo sapiens (Human)
Description:
O75381
Residue:
377
Sequence:
MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
  
Component 2
Name:
PEX5-related protein
Synonyms:
PEX2-related protein | PEX5-like protein | PEX5L | PEX5R | PEX5R_HUMAN | PXR2 | Peroxin-5-related protein | Peroxisome biogenesis factor 5-like | Pex5Rp | TRIP8b | Tetratricopeptide repeat-containing Rab8b-interacting protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69680.62
Organism:
Homo sapiens (Human)
Description:
Q8IYB4
Residue:
626
Sequence:
MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAPTQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP
  
Inhibitor
Name:
BDBM303929
Synonyms:
US10138242, Compound 15
Type:
Small organic molecule
Emp. Form.:
C38H41N5O3
Mol. Mass.:
615.7638
SMILES:
COc1ccc(CN2CCc3c(C2)c(nn3C2CN(C2)C(=O)C(C)(C)C)C(=O)NCc2cccc3ccccc23)c2ccccc12
Structure:
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