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Target
TGF-beta receptor type-1
Ligand
BDBM304166
Substrate
n/a
Meas. Tech.
Cell-Free Assay for Evaluating Inhibition of ALK5 Kinase Phosphorylatio
IC50
25.4±n/a nM
Citation
 Kim, D; Sheen, YY; Jin, C; Park, C; Domalapally, S; Kota, SR; Maddeboina, K; Vura Bala, S Methods of treating fibrosis, cancer and vascular injuries US Patent  USRE47141 Publication Date 11/27/2018 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM304166
Synonyms:
USRE47141, Example 149
Type:
Small organic molecule
Emp. Form.:
C22H17FN6O
Mol. Mass.:
400.4084
SMILES:
Cc1cccc(n1)-c1[nH]c(COc2ccccc2F)nc1-c1ccc2ncnn2c1
Structure:
Search PDB for entries with ligand similarity: