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Target
Programmed cell death 1 ligand 1 [19-239]
Ligand
BDBM304277
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay
IC50
55±n/a nM
Citation
 Allen, MP; Gillis, EP; Langley, DR; Miller, MM; Mull, E; Sun, L; Yeung, K; Grant-Young, KA; Meanwell, NA; Scola, PM Immunomodulators US Patent  US10143746 Publication Date 12/4/2018 
Target
Name:
Programmed cell death 1 ligand 1 [19-239]
Synonyms:
B7H1 | CD274 | Human PD-L1(aa 19-239)-TVMV-His | PD-L1-His | PD1L1_HUMAN | PDCD1L1 | PDCD1LG1 | PDL1 | hPDL1(aa 19-239)-TVMV-His
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27167.37
Organism:
Homo sapiens (Human)
Description:
Q9NZQ7[19-239]
Residue:
237
Sequence:
FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTGSSETVRFQGHHHHHH
  
Inhibitor
Name:
BDBM304277
Synonyms:
US10143746, Example 1501
Type:
Small organic molecule
Emp. Form.:
C87H117N21O20S
Mol. Mass.:
1809.054
SMILES:
CCCC[C@@H]1N(C)C(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCNC(=O)CC[C@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CSC[C@H](NC(=O)[C@H](C)NC1=O)C(=O)NCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N2 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
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