Target
Kelch-like ECH-associated protein 1 [321-609]
Ligand
BDBM304726
Substrate
n/a
Meas. Tech.
Nrf2-Keap1 FP Assay #1
IC50
55±n/a nM
Citation
 Davies, TGWoolford, AJWillems, HMNorton, DHeightman, TDKerns, JK Nrf2 regulators US Patent  US10144731 Publication Date 12/4/2018 
Target
Name:
Kelch-like ECH-associated protein 1 [321-609]
Synonyms:
INRF2 | KEAP1 | KEAP1_HUMAN | KIAA0132 | KLHL19 | Keap1 (aa 321-609)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31620.58
Organism:
Homo sapiens (Human)
Description:
Q14145[321-609]
Residue:
289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
  
Inhibitor
Name:
BDBM304726
Synonyms:
3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-(((S)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)propanoic acid | US10144731, Example 12
Type:
Small organic molecule
Emp. Form.:
C28H30N4O5S
Mol. Mass.:
534.627
SMILES:
C[C@H]1CN(Cc2cc(ccc2C)C(CC(O)=O)c2ccc3n(C)nnc3c2C)S(=O)(=O)c2ccccc2O1 |r|
Structure:
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