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TargetKeap1 (321-609)
LigandBDBM304740
Substrate/Competitorn/a
Meas. Tech.Nrf2-Keap1 FP Assay #1
IC50<10±n/a nM
Citation Davies, TGWoolford, AJWillems, HMNorton, DHeightman, TDKerns, JK Nrf2 regulators US Patent US10144731 Publication Date 12/4/2018
More Info.:Get all data from this article,  Assay Method
 
Keap1 (321-609)
Name:Keap1 (321-609)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:31620.58
Organism:Homo sapiens (Human)
Description:n/a
Residue:289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR
NNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSV
ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI
TAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT
VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
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  Blast E-value cutoff:
BDBM304740
NameBDBM304740
Synonyms:3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-((5-ethyl-1,1-dioxido-4,5-dihydropyrido[2,3-f][1,2,5]thiadiazepin-2(3H)-yl)methyl)-4-methylphenyl)propanoic acid | US10144731, Example 26
TypeSmall organic molecule
Emp. Form.C28H32N6O4S
Mol. Mass.548.656
SMILESCCN1CCN(Cc2cc(ccc2C)C(CC(O)=O)c2ccc3n(C)nnc3c2C)S(=O)(=O)c2cccnc12
Structure
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