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TargetKeap1 (321-609)
LigandBDBM304746
Substrate/Competitorn/a
Meas. Tech.Nrf2-Keap1 FP Assay #1
IC50 55±n/a nM
Citation Davies, TGWoolford, AJWillems, HMNorton, DHeightman, TDKerns, JK Nrf2 regulators US Patent US10144731 Publication Date 12/4/2018
More Info.:Get all data from this article,  Assay Method
 
Keap1 (321-609)
Name:Keap1 (321-609)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:31620.58
Organism:Homo sapiens (Human)
Description:n/a
Residue:289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR
NNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSV
ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI
TAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT
VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
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  Blast E-value cutoff:
BDBM304746
NameBDBM304746
Synonyms:3-(3-((4-ethyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)propanoic acid | US10144731, Example 32
TypeSmall organic molecule
Emp. Form.C28H30N4O5S
Mol. Mass.534.627
SMILESCCC1CN(Cc2cc(ccc2C)C(CC(O)=O)c2ccc3n(C)nnc3c2)S(=O)(=O)c2ccccc2O1
Structure
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