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TargetKeap1 (321-609)
LigandBDBM304766
Substrate/Competitorn/a
Meas. Tech.Nrf2-Keap1 FP Assay #1
IC50 55±n/a nM
Citation Davies, TGWoolford, AJWillems, HMNorton, DHeightman, TDKerns, JK Nrf2 regulators US Patent US10144731 Publication Date 12/4/2018
More Info.:Get all data from this article,  Assay Method
 
Keap1 (321-609)
Name:Keap1 (321-609)
Synonyms:n/a
Type:Enzyme Catalytic Domain
Mol. Mass.:31620.58
Organism:Homo sapiens (Human)
Description:n/a
Residue:289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR
NNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSV
ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI
TAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT
VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM304766
NameBDBM304766
Synonyms:(3R)-3-(1,4-dimethyl-1H-1,2,3-benzotriazol-5-yl)-3-{4-methyl-3-[(N-methylbenzenesulfonamido)methyl]phenyl}propanoic acid | US10144731, Example 55
TypeSmall organic molecule
Emp. Form.C26H28N4O4S
Mol. Mass.492.59
SMILESCN(Cc1cc(ccc1C)[C@@H](CC(O)=O)c1ccc2n(C)nnc2c1C)S(=O)(=O)c1ccccc1 |r|
Structure
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