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Target
Kelch-like ECH-associated protein 1 [321-609]
Ligand
BDBM304932
Substrate
n/a
Meas. Tech.
Nrf2-Keap1 FP Assay #1
IC50
550±n/a nM
Citation
 Davies, TG; Woolford, AJ; Willems, HM; Norton, D; Heightman, TD; Kerns, JK Nrf2 regulators US Patent  US10144731 Publication Date 12/4/2018 
Target
Name:
Kelch-like ECH-associated protein 1 [321-609]
Synonyms:
INRF2 | KEAP1 | KEAP1_HUMAN | KIAA0132 | KLHL19 | Keap1 (aa 321-609)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31620.58
Organism:
Homo sapiens (Human)
Description:
Q14145[321-609]
Residue:
289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
  
Inhibitor
Name:
BDBM304932
Synonyms:
3-(4-Methyl-3-(((R)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)-3-(o-tolyl)propanoic acid | US10144731, Example 236
Type:
Small organic molecule
Emp. Form.:
C27H29NO5S
Mol. Mass.:
479.588
SMILES:
C[C@@H]1CN(Cc2cc(ccc2C)C(CC(O)=O)c2ccccc2C)S(=O)(=O)c2ccccc2O1 |r|
Structure:
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