Target
Lethal factor
Ligand
BDBM8489
Substrate
Peptide Substrate
Meas. Tech.
Fluorescence Resonance Energy Transfer Assay (FRET)
IC50
1640±n/a nM
Citation
 Xiong, YWiltsie, JWoods, AGuo, JPivnichny, JVTang, WBansal, ACummings, RTCunningham, BRFriedlander, AMDouglas, CMSalowe, SPZaller, DMScolnick, EMSchmatz, DMBartizal, KHermes, JDMacCoss, MChapman, KT The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett 16:964-8 (2006) [PubMed]  Article 
Target
Name:
Lethal factor
Synonyms:
Anthrax Lethal Factor (LF) | Anthrax lethal factor | Antrax lethal toxin | LEF_BACAN | lef | lethal factor
Type:
PROTEIN
Mol. Mass.:
93758.56
Organism:
Bacillus anthracis
Description:
ChEMBL_1460338
Residue:
809
Sequence:
MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
  
Inhibitor
Name:
BDBM8489
Synonyms:
(2R)-N-hydroxy-2-[(4-hydroxy-3-methylbenzene)sulfonamido]-3-methylbutanamide | hydroxamate analogue 26
Type:
Small organic molecule
Emp. Form.:
C12H18N2O5S
Mol. Mass.:
302.347
SMILES:
CC(C)[C@@H](NS(=O)(=O)c1ccc(O)c(C)c1)C(=O)NO |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Peptide Substrate
Synonyms:
(Cou)Consensus(K(QSY-35)GG)-NH2
Type:
Peptide
Mol. Mass.:
9139.37
Organism:
n/a
Description:
n/a
Residue:
78
Sequence:
HYDRYMETHYLACETYLCMARINYLNLEKKKKVLPIQLNAATDKNNITRENADIALYLAMINPHENYLACETYLGGNH