Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM306264
Substrate
n/a
Meas. Tech.
NAMPT Enzyme Assay
IC50
<100±n/a nM
Citation
 Gigstad, KM; Cardin, DP; Hirayama, T; Hirose, M; Hu, Y; Kakei, H; Lee, HM; Motoyaji, T; Nii, N; Shi, Z; Vyskocil, S; Watanabe, H Quinoxaline compounds and uses thereof US Patent  US10144742 Publication Date 12/4/2018 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM306264
Synonyms:
US10144742, Compound I-426
Type:
Small organic molecule
Emp. Form.:
C27H24FN5O3
Mol. Mass.:
485.5096
SMILES:
COc1cc(ccc1F)-c1nc2cc(ccc2nc1OC(C)C)C(=O)NCc1ccc2nccn2c1
Structure:
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