Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM307608
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
3954±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y; Skudlarek, JW Pyrrolidine orexin receptor antagonists US Patent  US10150751 Publication Date 12/11/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM307608
Synonyms:
((2S,4S)-4-((4-methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(2- (trifluoromethoxy)phenyl)methanone | US10150751, Example 47
Type:
Small organic molecule
Emp. Form.:
C19H20F3N3O3
Mol. Mass.:
395.3756
SMILES:
COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1ccccc1OC(F)(F)F |r|
Structure:
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