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Target
Beta-secretase 1 [1-460]
Ligand
BDBM307705
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
640±n/a nM
Citation
 Minidis, A; Rahm, F; Viklund, J Mono-fluoro beta-secretase inhibitors US Patent  US9650336 Publication Date 5/16/2017 
Target
Name:
Beta-secretase 1 [1-460]
Synonyms:
BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE1) | Beta-secretase 1 (aa 1-460) | KIAA1149
Type:
Protein
Mol. Mass.:
50987.78
Organism:
Homo sapiens (Human)
Description:
P56817[1-460]
Residue:
460
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAY
  
Inhibitor
Name:
BDBM307705
Synonyms:
US9650336, Example 8
Type:
Small organic molecule
Emp. Form.:
C20H17F3N2O
Mol. Mass.:
358.357
SMILES:
CC1(C)COc2ccc(cc2C11C=C(F)C(N)=N1)-c1cc(F)cc(F)c1 |c:18,t:14|
Structure:
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