Target
Growth arrest-specific protein 6
Ligand
BDBM308305
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
14.0±n/a nM
Citation
 Wang, XZhang, WFrye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent  US9649309 Publication Date 5/16/2017 
Target
Name:
Growth arrest-specific protein 6
Synonyms:
AXL receptor tyrosine kinase ligand | AXLLG | GAS-6 | GAS6 | GAS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
74914.43
Organism:
Homo sapiens (Human)
Description:
Q14393
Residue:
678
Sequence:
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
  
Inhibitor
Name:
BDBM308305
Synonyms:
US9649309, Compound UNC4223A
Type:
Small organic molecule
Emp. Form.:
C22H34N6OS
Mol. Mass.:
430.61
SMILES:
CCCCNc1ncc(-c2ncc(CN3CCCC3)s2)c(NC2CC[C@H](O)CC2)n1 |r,wD:25.27,(-8.41,-3.85,;-7.07,-3.08,;-5.74,-3.85,;-4.41,-3.08,;-3.07,-3.85,;-1.74,-3.08,;-.4,-3.85,;.93,-3.08,;.93,-1.54,;2.26,-.77,;2.26,.77,;3.73,1.25,;4.63,,;6.17,,;6.94,-1.33,;8.41,-1.81,;8.41,-3.35,;6.94,-3.83,;6.04,-2.58,;3.73,-1.25,;-.4,-.77,;-.4,.77,;-1.74,1.54,;-3.07,.77,;-4.41,1.54,;-4.41,3.08,;-5.74,3.85,;-3.07,3.85,;-1.74,3.08,;-1.74,-1.54,)|
Structure:
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