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Target
Growth arrest-specific protein 6
Ligand
BDBM308313
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
867±n/a nM
Citation
 Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent  US9649309 Publication Date 5/16/2017 
Target
Name:
Growth arrest-specific protein 6
Synonyms:
AXL receptor tyrosine kinase ligand | AXLLG | GAS-6 | GAS6 | GAS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
74914.43
Organism:
Homo sapiens (Human)
Description:
Q14393
Residue:
678
Sequence:
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
  
Inhibitor
Name:
BDBM308313
Synonyms:
US9649309, Compound UNC4333A
Type:
Small organic molecule
Emp. Form.:
C28H39N7O
Mol. Mass.:
489.6556
SMILES:
CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1cc(Nc2cccc(c2)C(C)(C)C)ncn1 |r,wU:11.10,wD:14.14,(-10.67,-3.85,;-9.34,-3.08,;-8,-3.85,;-6.67,-3.08,;-5.33,-3.85,;-4,-3.08,;-2.67,-3.85,;-1.33,-3.08,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-4,1.54,;-5.33,.77,;-6.67,1.54,;-6.67,3.08,;-8,3.85,;-5.33,3.85,;-4,3.08,;-4,-1.54,;,-.77,;1.33,-1.54,;2.67,-.77,;4,-1.54,;5.33,-.77,;5.33,.77,;6.67,1.54,;8,.77,;8,-.77,;6.67,-1.54,;9.34,-1.54,;9.34,-3.08,;10.67,-.77,;10.67,-2.31,;2.67,.77,;1.33,1.54,;,.77,)|
Structure:
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