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Target
Growth arrest-specific protein 6
Ligand
BDBM308337
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
3.20±n/a nM
Citation
 Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent  US9649309 Publication Date 5/16/2017 
Target
Name:
Growth arrest-specific protein 6
Synonyms:
AXL receptor tyrosine kinase ligand | AXLLG | GAS-6 | GAS6 | GAS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
74914.43
Organism:
Homo sapiens (Human)
Description:
Q14393
Residue:
678
Sequence:
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
  
Inhibitor
Name:
BDBM308337
Synonyms:
US9649309, Compound UNC4244A
Type:
Small organic molecule
Emp. Form.:
C26H31FN6O
Mol. Mass.:
462.5623
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccccc2F)ncc1-c1ccc(CN2CCCC2)cn1 |r,wU:4.7,wD:1.0,(-7.19,4.62,;-5.85,3.85,;-5.85,2.31,;-4.52,1.54,;-3.19,2.31,;-3.19,3.85,;-4.52,4.62,;-1.85,1.54,;-1.85,,;-3.19,-.77,;-3.19,-2.31,;-4.52,-3.08,;-5.85,-2.31,;-5.85,-.77,;-7.19,,;-8.52,-.77,;-8.52,-2.31,;-7.19,-3.08,;-7.19,-4.62,;-1.85,-3.08,;-.52,-2.31,;-.52,-.77,;.82,,;2.15,-.77,;3.48,,;3.48,1.54,;4.82,2.31,;6.15,1.54,;6.15,,;7.61,-.48,;8.52,.77,;7.61,2.02,;2.15,2.31,;.82,1.54,)|
Structure:
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