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Target
Kappa-type opioid receptor
Ligand
BDBM309418
Substrate
n/a
Meas. Tech.
ORL-1 Receptor Binding Assay
EC50
25.7±4.99 nM
Citation
 Lockman, J; Tafesse, L Ring-contracted morphinans and the use thereof US Patent  US9656962 Publication Date 5/23/2017 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM309418
Synonyms:
(2R,3aS,4R,9bS)-2-amino-12- (cyclopropylmethyl)-1,2,3,3a,4,5- hexahydro-4,9b-(epiminoethano)- cyclopenta[a]naphthalene-3a,8-diol | US9656962, Compound 22
Type:
Small organic molecule
Emp. Form.:
C19H26N2O2
Mol. Mass.:
314.4219
SMILES:
N[C@H]1C[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@]2(C1)CCN3CC1CC1 |r,TLB:19:18:3:13.7.6|
Structure:
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