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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM309955
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
IC50
172000±n/a nM
Citation
 Buchholz, M; Heiser, U; Niestroj, AJ; Sommer, R Inhibitors of glutaminyl cyclase US Patent  US9656991 Publication Date 5/23/2017 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM309955
Synonyms:
N-(1H-benzo[d]- imidazol-5-yl)- piperidine-1- carbothioamide | US9656991, 69
Type:
Small organic molecule
Emp. Form.:
C13H16N4S
Mol. Mass.:
260.358
SMILES:
S=C(Nc1ccc2[nH]cnc2c1)N1CCCCC1
Structure:
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