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TargetLeukocyte elastase
LigandBDBM310019
Substrate/Competitorn/a
Meas. Tech.Neutrophil Elastase Assay
IC50<1.000±n/a nM
Citation Gnamm, CAnderskewitz, RHoesch, HMorschhaeuser, GOost, TPeters, SRies, UJ Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent US9657015 Publication Date 5/23/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM310019
NameBDBM310019
Synonyms:US9657015, Example 12 | US9657015, Example 12.1 | US9657015, Example 12.2 | US9657015, Example 12.3 | US9657015, Example 12.4 | US9657015, Example 12.5 | US9657015, Example 12.6 | US9657015, Example 12.7 | US9657015, Example 12.8 | US9657015, Example 12.9
TypeSmall organic molecule
Emp. Form.C24H20F3N5O3
Mol. Mass.483.4425
SMILESCNC(=O)CN1C(C2=C(CCNC2=O)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C#N |t:7|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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