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Target
Neutrophil elastase
Ligand
BDBM310046
Substrate
n/a
Meas. Tech.
Neutrophil Elastase Assay
IC50
2.70±n/a nM
Citation
 Gnamm, C; Anderskewitz, R; Hoesch, H; Morschhaeuser, G; Oost, T; Peters, S; Ries, UJ Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent  US9657015 Publication Date 5/23/2017 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM310046
Synonyms:
US9657015, Example 15 | US9657015, Example 15.1 | US9657015, Example 15.2 | US9657015, Example 15.3 | US9657015, Example 15.4 | US9657015, Example 15.5 | US9657015, Example 15.6
Type:
Small organic molecule
Emp. Form.:
C25H22F3N5O3
Mol. Mass.:
497.4691
SMILES:
CNC(=O)CN1C(C2=C(CCN(C)C2=O)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1)C#N |t:7|
Structure:
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