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Target
Nuclear receptor ROR-gamma
Ligand
BDBM310627
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
18.0±n/a nM
Citation
 Goldberg, S; Venkatesan, H; Kinzel, O; Gege, C; Steeneck, C; Kleymann, G; Hoffmann, T Trifluoromethyl alcohols as modulators of RORγt US Patent  US10150762 Publication Date 12/11/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM310627
Synonyms:
US10150762, Example 2/12
Type:
Small organic molecule
Emp. Form.:
C22H19Cl2F8N3O4S
Mol. Mass.:
644.362
SMILES:
CC(C)(O)CNC(=O)c1nc(C(=O)N2CCC(F)(F)C2)c(s1)-c1ccc(c(Cl)c1Cl)C(O)(C(F)(F)F)C(F)(F)F
Structure:
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