Target
Nuclear receptor ROR-gamma
Ligand
BDBM310658
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
2.10±n/a nM
Citation
 Goldberg, SVenkatesan, HKinzel, OGege, CSteeneck, CKleymann, GHoffmann, T Trifluoromethyl alcohols as modulators of RORγt US Patent  US10150762 Publication Date 12/11/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM310658
Synonyms:
(4-(7-Azabicyclo[2.2.11]heptane-7-carbonyl)-5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiazol-2-yl)((3R,5S)-3,5-dihydroxypiperidin-1-yl)methanone | US10150762, Example 10
Type:
Small organic molecule
Emp. Form.:
C25H23Cl2F6N3O5S
Mol. Mass.:
662.429
SMILES:
O[C@H]1C[C@@H](O)CN(C1)C(=O)c1nc(C(=O)N2C3CCC2CC3)c(s1)-c1ccc(c(Cl)c1Cl)C(O)(C(F)(F)F)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: