Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM310736
Substrate
n/a
Meas. Tech.
HDAC inhibitory assay
IC50
5500±n/a nM
Citation
 Shuttleworth, SJ; Tomassi, CD; Cecil, AR; MacCormick, S; Nodes, WJ; Silva, FA Histone deacetylase inhibitors and their use in therapy US Patent  US10150763 Publication Date 12/11/2018 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM310736
Synonyms:
8-(Benzo[d]thiazol-2-yl(pyridin-2-yl)amino)-N-hydroxyoctanamide | US10150763, Example JJ
Type:
Small organic molecule
Emp. Form.:
C20H24N4O2S
Mol. Mass.:
384.495
SMILES:
ONC(=O)CCCCCCCN(c1nc2ccccc2s1)c1ccccn1
Structure:
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