Reaction Details
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Sodium/glucose cotransporter 1
Ligand
BDBM176703
Substrate
n/a
Meas. Tech.
In Vitro Human SGLT1 Inhibition Assay
pH
7.3±n/a
IC50
<10.00±n/a nM
Comments
extracted
Citation
Carson, KG; Goodwin, NC; Harrison, BA; Rawlins, DB; Strobel, E; Zambrowicz, B Inhibitors of sodium glucose cotransporter 1 US Patent US9688710 Publication Date 6/27/2017 More Info.:
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
Inhibitor
Name:
BDBM176703
Synonyms:
US9688710, 126 (S,R,S,R,R)-1,1′-(4,4′-(propane-1,3-diyl)bis(piperazine-4,1-diyl))bis(4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butan-1-one)
Type:
Small organic molecule
Emp. Form.:
C59H80N4O10S2
Mol. Mass.:
1069.417
SMILES:
CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)N3CCN(CCCN4CCN(CC4)C(=O)CCCc4ccc(Cc5cc(ccc5C)[C@@H]5O[C@H](SC)[C@@H](O)[C@H](O)[C@H]5O)cc4)CC3)cc2)c1 |r|
Structure:
