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TargetBRD4 BD1 (aa 42-168)
LigandBDBM310878
Substrate/Competitorn/a
Meas. Tech.BRD4 AlphaLisa Binding Assay
IC50 110±n/a nM
Citation Albrecht, BKBellon, SFBurdick, DJCote, ACrawford, TDakin, LAHsiao-Wei Tsui, VHewitt, MCLeBlanc, YMagnuson, SRNasveschuk, CGRomero, AFTang, YTaylor, AMWang, S Therapeutic compounds and uses thereof US Patent US10150767 Publication Date 12/11/2018
More Info.:Get all data from this article,  Assay Method
 
BRD4 BD1 (aa 42-168)
Name:BRD4 BD1 (aa 42-168)
Synonyms:Bromodomain-containing protein 4 Bromo Domain 1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (Human)
Description:n/a
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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  Blast E-value cutoff:
BDBM310878
NameBDBM310878
Synonyms:3-isopropyl-6-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-1H-quinoxalin-2-one | US10150767, Example 14
TypeSmall organic molecule
Emp. Form.C19H20N4O2
Mol. Mass.336.3877
SMILESCC(C)C1Nc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
Structure
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n/a