Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM212529
Substrate
n/a
Meas. Tech.
Inhibitory Activity Against Human Renin
IC50
62.0±n/a nM
Citation
 Iijima, T; Sugama, H; Kawaguchi, T; Shen, J; Xia, G; Xie, J; Hirai, M Nitrogen-containing saturated heterocyclic compound US Patent  US10155731 Publication Date 12/18/2018 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM212529
Synonyms:
US10155731, Example 92 | US9278944, 92
Type:
Small organic molecule
Emp. Form.:
C22H32ClN5O2
Mol. Mass.:
433.975
SMILES:
COCCCn1nc(C)c2c(Cl)cc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCN1 |r|
Structure:
Search PDB for entries with ligand similarity: