Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM311082
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
10000±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Amidoethyl azole orexin receptor antagonists US Patent  US10155750 Publication Date 12/18/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM311082
Synonyms:
N-ethyl-N-(2-(4-(2- hydroxypropan-2-yl)-2H-1,2,3- triazol-2-yl)ethyl)-2- isopropoxybenzamide | US10155750, Example 18
Type:
Small organic molecule
Emp. Form.:
C19H28N4O3
Mol. Mass.:
360.4506
SMILES:
CCN(CCn1ncc(n1)C(C)(C)O)C(=O)c1ccccc1OC(C)C
Structure:
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