Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM311103
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
1174±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Amidoethyl azole orexin receptor antagonists US Patent  US10155750 Publication Date 12/18/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM311103
Synonyms:
2-cyclobutyl-N-ethyl- N-(2-(4-(2- hydroxypropan-2-yl)- 5-methyl-2H-1,2,3- triazol-2- yl)ethyl)benzamide | US10155750, Example 40
Type:
Small organic molecule
Emp. Form.:
C21H30N4O2
Mol. Mass.:
370.4885
SMILES:
CCN(CCn1nc(C)c(n1)C(C)(C)O)C(=O)c1ccccc1C1CCC1
Structure:
Search PDB for entries with ligand similarity: