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Target
Tyrosine-protein kinase SYK [342-635]
Ligand
BDBM311115
Substrate
n/a
Meas. Tech.
SYK Kinase Inhibition Test
IC50
1.30±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018 
Target
Name:
Tyrosine-protein kinase SYK [342-635]
Synonyms:
KSYK_HUMAN | SYK | SYK (aa 342-635)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34105.36
Organism:
Homo sapiens (Human)
Description:
P43405[342-635]
Residue:
294
Sequence:
PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM311115
Synonyms:
US10155751, Example 2
Type:
Small organic molecule
Emp. Form.:
C20H24FN5O2
Mol. Mass.:
385.4353
SMILES:
CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(F)n(C)nc2c1 |r|
Structure:
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