Target
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Ligand
BDBM311135
Substrate
n/a
Meas. Tech.
FLT3 Kinase Test
IC50
1948±n/a nM
Citation
 Hoffmann, MDahmann, GGnamm, CFandrick, DRScott, JMcCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3 (aa 564-960) | FLT3_HUMAN | STK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45855.41
Organism:
Homo sapiens (Human)
Description:
P36888[564-960]
Residue:
397
Sequence:
HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
  
Inhibitor
Name:
BDBM311135
Synonyms:
US10155751, Example 22
Type:
Small organic molecule
Emp. Form.:
C23H27F2N5O2
Mol. Mass.:
443.4896
SMILES:
C[C@@H](Oc1cc(cc2nn(C)c(C)c12)-c1cnn(c1)C1CCC(F)(F)C1)[C@H]1CNC(=O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: