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Target
Aurora kinase B [1-341]
Ligand
BDBM311136
Substrate
n/a
Meas. Tech.
Aurora B Kinase Test
IC50
162±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018 
Target
Name:
Aurora kinase B [1-341]
Synonyms:
AIK2 | AIM1 | AIRK2 | ARK2 | AURB (aa 1-341) | AURKB | AURKB_HUMAN | STK1 | STK12 | STK5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39070.43
Organism:
Homo sapiens (Human)
Description:
Q96GD4[1-341]
Residue:
341
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQ
  
Inhibitor
Name:
BDBM311136
Synonyms:
example 5.20 on page 506 of WO15017610
Type:
Small organic molecule
Emp. Form.:
C20H26N6O2
Mol. Mass.:
382.4594
SMILES:
C[C@@H](Oc1nc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Structure:
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