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Target
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Ligand
BDBM311140
Substrate
n/a
Meas. Tech.
FLT3 Kinase Test
IC50
6677±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [564-960]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3 (aa 564-960) | FLT3_HUMAN | STK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45855.41
Organism:
Homo sapiens (Human)
Description:
P36888[564-960]
Residue:
397
Sequence:
HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
  
Inhibitor
Name:
BDBM311140
Synonyms:
example 6.60 on page 587 of WO15017610
Type:
Small organic molecule
Emp. Form.:
C21H27N5O2
Mol. Mass.:
381.4714
SMILES:
C[C@@H](Oc1cc(cn2nc(C)cc12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r|
Structure:
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