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Target
TGF-beta receptor type-1
Ligand
BDBM311395
Substrate
n/a
Meas. Tech.
Inhibition of ALK5 Kinase Phosphorylation
IC50
6.60±n/a nM
Citation
 Lee, JY; Ryu, K; Kim, J; Kim, Y; Shin, D; Lee, B; Kang, S; Lee, H; Jung, H; Shin, YA; Park, E; Ahn, J; Kim, H; Ryu, JH 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors US Patent  US10155763 Publication Date 12/18/2018 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM311395
Synonyms:
US10155763, Example 2
Type:
Small organic molecule
Emp. Form.:
C19H16N6
Mol. Mass.:
328.3705
SMILES:
Cc1cccc(n1)-c1nc2NCCn2c1-c1ccc2nccnc2c1
Structure:
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