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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM311550
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
670±n/a nM
Citation
 Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent  US10155765 Publication Date 12/18/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM311550
Synonyms:
US10155765, Example 46 | tert-butyl 4-{3-carbamoyl-4- [(pyrazolo[1,5-a]pyrimidin- 3-ylcarbonyl)amino]-1H- pyrazol-1-yl}piperidine-1- carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H26N8O4
Mol. Mass.:
454.4823
SMILES:
CC(C)(C)OC(=O)N1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)C(N)=O
Structure:
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