Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM311552
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
650±n/a nM
Citation
Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent US10155765 Publication Date 12/18/2018
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM311552
Synonyms:
N-{3-carbamoyl-1-[1- (methylsulfonyl)piperidin-4- yl]-1H-pyrazol-4- yl}pyrazolo[1,5- a]pyrimidine-3-carboxamide | US10155765, Example 48
Type:
Small organic molecule
Emp. Form.:
C17H20N8O4S
Mol. Mass.:
432.457
SMILES:
CS(=O)(=O)N1CCC(CC1)n1cc(NC(=O)c2cnn3cccnc23)c(n1)C(N)=O