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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM311561
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
2.00±n/a nM
Citation
 Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent  US10155765 Publication Date 12/18/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM311561
Synonyms:
2-[(2- aminoethyl)amino]-N- [3-carbamoyl-1-(2- hydroxyethyl)-1H- pyrazol-4- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate | US10155765, Example 59
Type:
Small organic molecule
Emp. Form.:
C15H19N9O3
Mol. Mass.:
373.3699
SMILES:
NCCNc1ncc2ccc(C(=O)Nc3cn(CCO)nc3C(N)=O)n2n1
Structure:
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