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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM311767
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.251±n/a nM
Citation
 Ameriks, MK; Laforteza, BN; Lebold, TP; Ravula, S; Savall, BM; Shireman, BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent  US10155769 Publication Date 12/18/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM311767
Synonyms:
6-(7-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzo[d]thiazol-2(3H)-one | US10155769, Example 5
Type:
Small organic molecule
Emp. Form.:
C20H10F4N4OS
Mol. Mass.:
430.378
SMILES:
Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F
Structure:
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